Why do you see Dyslipidemia in Thyroid Disorders - A Quick Review

Do you know why dyslipidemia is seen in thyroid disorders? Please watch the video to know why!

Explanation to USMLE style Biochemistry Question on Hypothyroidism

Please watch the video to know the question details and also each choice is right or wrong!

Note: in the initial part of the video I said the diagnosis is hypoparathydoidism by mistake, read it as HYPOTHYROIDISM.

Review on Cobalamin for USMLE Step-1

In this video I have reviewed all high yield points about cobalamin: source, functions, causes for deficiency, deficiency manifestation of cobalamin.

Explanation for a Kaplan Question on Enzyme Kinetics

In the following video I have explained in detail about the correct answer to a Kaplan question on enzyme kinetics and also I have explained why other choices are wrong. I have touched up on the concepts like Km, Vmax, affinity-Km relation, non-competitive inhibition and effect of enzyme concentration on the reaction.

Kaplan Question for you on Enzymes!

Why do you think the choice you have chosen is correct? 

Discuss in the comments section below!

Omega 6 and Omega 3 PUFAs in relation to inflammation

I would like to bring to your attention about Comparison between omega 6 and omega 3 PUFAs with respect to inflammation. 

We are debating here on good vs good, both omega 6 and omega 3 are good for our body in their own way. As we all know inflammation is a good thing but not always, controlled inflammation is a good thing, when inflammation goes uncontrolled that leads to acute and chronic inflammatory diseases. All this mediated by inflammatory mediators which are largely from our two class of PUFAs. Omega 6 and omega-3. 

As you might be knowing we need to get these omega FAs from plant source as linoleic acid (omega 6) and linoleic acid (omega3), in our body linoleic acid is converted arachidonic acid (omeg6) whereas linoleic acid into DHA and EPA (omega3) which are incorporated into membrane. 

In response to injury there will be activation of phospholipase A2 which breaks and release these membrane lipids and further they go on to make inflammatory mediators. 

Arachidonic acid (omega6) largely form pro-inflammatory mediators and increases inflammation including platelet aggregation, it also makes pro-resolving mediators like lipoxins. 

Whereas DHA and EPA will form predominantly anti-inflammatory, pro-resolving and cytoprotectants like E series resolvins, D-series resolvins, protectins, neuroprotectins, meresins which all participate in resolving the inflammation and protecting the cell. 

So by adequately consuming omega3 PUFAs we are trying to keep things in balance and protect from uncontrolled inflammation which could lead to variety of disease conditions include thromboembolism. 

Hence it is all about keeping homeostasis by consuming omega6, omega3, MUFA and saturated fatty acids all in balance because we need all of them but in balance. 

Hope this explanation helps some of you to understand this very important concept.

Bohr Shift and Haldane Effect

In this video I have explained about the Bohr Shift and Haldane effect on the interaction of hemoglobin with O2 and H+ with the help of a question. Watch the video to know the answer to the question and also to learn abut Bohr shift and Haldane effect.

Biochemistry USMLE Style Question

Explain your answer why do you think you the choice you have chosen is correct.

A Quick Review on Oxygen Dissociation Curve for USMLE Step-1

In this video I have explained the oxygen dissociation curve for hemoglobin and myoglobin. While explaining that I have touched upon the mechanism of oxygen dissociation, function of these two molecules and their affinities for oxygen.

A Quick Review on Amino Acids (structure and all types of classifications for USMLE Step-1

In this video I have explained the basic structure of amino acids, pH and Pka relation, various types of classification of amino acids. 

Explanation for a question on Prion disease

In this video I'm explaining the answer to one of my question on Prion disease. You can pause the video to answer yourself to this question. You can continue to play the video to know in brief about Prion disease and the explanation for the question.

Explanation for a Question on Beta Bends of a Protein Molecule

In the following video I have briefly explained on protein folding process and the structural organization of a protein molecules. I have given explanation to one of my question on beta bends of a protein molecule.