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I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!

Friday, March 8, 2013

Why regular consumption of carbohydrate rich diet makes you fatty????!!!

Most of us do care about how we look physically, we do and try every thing that we can (although some do it religiously and some once in a while) to be physically fit and look good!!! Ideally optimum balanced diet and regular exercise will maintain the normal weight but some times it becomes difficult to follow this.There may various reasons for this but most important and most common reason for not keeping up with regular exercise is that inherently we are lazy!! 

Despite being too lazy one can still maintain the normal body weight by just watching what they eat!! Eating too much of carbs will make one put on weight like a chicken and look like a hippo!! Why eating too much of carbs makes us fatty!!! its because of the following biochemical reasons!!

When we take too much of carbs, our blood glucose will shoot up and will lead to increased release of insulin. Insulin is an anabolic hormone and it will make all that is possible to conserve this glucose in the form of glycogen and fat in our body. The intention behind this is good!! The reason that insulin will help to store excess glucose as glycogen and fat is to create reserve energy in case when person gets into fasting and starvation.

This idea of storing when available plenty was well suited for our ancestors from hunter-gatherer era. In this era when the availability of food is plenty (of-course for those who are more fortunate compared to the people in third world countries where they suffer from malnutrition (read under nutrition). More fortunate person is the one who look like hippo when they don't really care how much they eat and what they eat!!

Insulin released in response to high glucose will keep all the necessary enzymes active so that glucose is converted to glycogen. When the glycogen stores are full, it will convert glucose to acetyl CoA which will be converted to fatty acids. This process occurs predominantly in the liver and the fatty acids are transported to other tissues including adipose tissue. Glucose can also be converted to acetyl CoA and converted to fatty acids in the adipose tissue. 

So excess carbs beyond the body energy needs are converted to fatty acids and these fatty acids in the liver and adipose tissue will be converted to triacylglycerol (TAG) and predominately stored in adipose tissue beneath the skin (white adipose tissue). Continuous accumulation of this TAG in adipose tissue without any utilization (because person is too lazy to burn!!) will lead to obesity. This is the reason why when a person consumes high carbs without much activity will look like a hippo!!

So idea is to limit the carbs in the diet and being conscious about what we eat. Following a simple rule of diet, high protein low carb low fat with lot of vegetables and fruits will keep our weight in check!!!  Hope this helps you to shed that extra pound and make you look good and fit!! 

Thank you for your time and you are most welcome to leave your concise criticism and comments!!

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