Let me introduce myself to you!!

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St. Kitts & Nevis
I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!

Thursday, March 23, 2017

Gluconeogenesis Precursors



This video is for quick review for USMLE step1 on precursors of gluconeogenesis and important enzymes. Some of the precursors discussed are alanine, lactate, glycerol and propionyl CoA. All important enzymes of gluconeogenesis is covered in the quick review on gluconeogenesis for USMLE step1.

Video link for detailed gluconeogenesis process
https://www.youtube.com/watch?v=vBCUbVdad8c&t=238s

Glycogen Storage Diseases



This video is a super fast high yield review for those who need a quick recap of all glycogen storage disorders for their step1 USMLE review or for any exam review. In this video I have covered all glycogen storage disorders like Von Gierke disease, Pompe disease, McArdle disease, Tarui disease, Hers disease, Andersen disease, Cori's disease. All high yield points are covered about all glycogen storage disorders.
Links for my videos on individual glycogen storage disorders are as below.
Von Gierke disease
https://www.youtube.com/watch?v=v9rmg_pdSt8
Pompe disease
https://www.youtube.com/watch?v=52g5YrExNWY&t=7s

I Cell Disease



In this video I have explained about chemical markers for protein targeting. Special focus is on mannose 6 phosphate marker for lysosomes. Lysosomal enzyme targeting to lysosomes with mannose 6 phosphate receptor. i cell disease is inclusion cell disease due to defect in GlcNAc phosphotransferase. The signs and symptoms are similar to hurler syndrome.

Link for Hurler syndrome
https://www.youtube.com/watch?v=1BcZkRxxc4Y


Sunday, March 19, 2017

Paraxysmal Nocturnal Hemoglobinuria (PNH)



This video is all about a rare clonal hematopoetic disorder called paroxysmal nocturnal hemoglobinuria abbreviated as PNH. PNH is because of the mutation in PIG A gene which codes for GPI (glycophosphotidylinositol). GPI is needed for anchoring DAF and CD59  on red cell membrane. In the absence of DAF and CD59 the red cells will be hemolysed by the compliment system. Complimented mediated hemolysis in paroxysmal nocturnal hemoglobinuria, PNH, leads to complement mediated intravascular hemolysis giving rise to hemoglobinuria, jaundice and anemia. PNH is diagnosed using sucrose hemolysis test or sugar water test, Hams test and flow cytometry. 

Proteoglycans and Glycosaminoglycans



In this video I have explained all that you need to know in proteoglycans and glycosaminoglycans. All in brief and high yield points.