Understanding cellular metabolic process will help us to
understand the disease process when some metabolic
events go wrong!! With this blog I would like to share my
medical biochemistry knowledge with you!!!
I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!
I would like to bring to your attention about Comparison between omega 6 and omega 3 PUFAs with respect to inflammation.
We are debating here on good vs good, both omega 6 and omega 3 are good for our body in their own way. As we all know inflammation is a good thing but not always, controlled inflammation is a good thing, when inflammation goes uncontrolled that leads to acute and chronic inflammatory diseases. All this mediated by inflammatory mediators which are largely from our two class of PUFAs. Omega 6 and omega-3.
As you might be knowing we need to get these omega FAs from plant source as linoleic acid (omega 6) and linoleic acid (omega3), in our body linoleic acid is converted arachidonic acid (omeg6) whereas linoleic acid into DHA and EPA (omega3) which are incorporated into membrane.
In response to injury there will be activation of phospholipase A2 which breaks and release these membrane lipids and further they go on to make inflammatory mediators.
Arachidonic acid (omega6) largely form pro-inflammatory mediators and increases inflammation including platelet aggregation, it also makes pro-resolving mediators like lipoxins.
Whereas DHA and EPA will form predominantly anti-inflammatory, pro-resolving and cytoprotectants like E series resolvins, D-series resolvins, protectins, neuroprotectins, meresins which all participate in resolving the inflammation and protecting the cell.
So by adequately consuming omega3 PUFAs we are trying to keep things in balance and protect from uncontrolled inflammation which could lead to variety of disease conditions include thromboembolism.
Hence it is all about keeping homeostasis by consuming omega6, omega3, MUFA and saturated fatty acids all in balance because we need all of them but in balance.
Hope this explanation helps some of you to understand this very important concept.
In this video I have explained about the Bohr Shift and Haldane effect on the interaction of hemoglobin with O2 and H+ with the help of a question. Watch the video to know the answer to the question and also to learn abut Bohr shift and Haldane effect.
In this video I have explained the oxygen dissociation curve for hemoglobin and myoglobin. While explaining that I have touched upon the mechanism of oxygen dissociation, function of these two molecules and their affinities for oxygen.