Let me introduce myself to you!!

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St. Kitts & Nevis
I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!

Sunday, November 13, 2016

Regulation of Fatty Acid Oxidation

In this video I have explained the regulation of fatty acid oxidation in the mitochondria. The regulation is mainly going on over outer mitochondrial membrane. The main regulatory molecule is malonyl CoA controlling the activity of CPT I or CAT I.

Carnitine Shuttle Mechanism

In this video I have explained the carnitine shuttle mechanism for transport of long chain fatty acids into the mitochondrial matrix for beta oxidation. Carnitine is synthesized in the liver using essential amino acids lysine and methionine. Carnitine shuttles back and forth between matrix and inter membrane space to transport LCFA into the matrix.

Beta Oxidation of a Fatty Acid

In this video I have explained all the reactions involved in beta-oxidation of even number saturated fatty acid. Beta oxidation of a fatty acid will take place in the mitochondrial matrix. Fatty acid will be oxidized into acetyl CoA which will undergo TCA cycle and ketone body synthesis. Oxidation of fatty acid needs sufficient riboflavin and niacin to maintain the coenzyme needs. Defect in oxidation can lead to impaired ATP generation under fasting condition. 

Introduction to Lipoproteins

In this video I have explained the basic points about lipoproteins. In introduction to lipoproteins I have explained the general structure of lipoproteins, the arrangement of most of the components of lipoproteins including apolipoproteins. Also I have explained the arrangement of lipoproteins according to the density, size, electrophoretic mobility, all the major apolipoproteins and other important apolipoproteins over lipoproteins.

Surfactant and Infant Respiratory Distress Syndrome (IRDS)

In this video I have explained about surfactant, composition of surfactant, differentiation of pneumocytes into type I pneumocytes and type II pneumocytes. Type of phospholipid in surfactant the major being dipalmitoyl phosphotidyl choline which is also called as dipalmitoyl lecithin. Deficiency of surfactant is seen in pre-mature babies and it will lead to infant respiratory distress syndrome which is seen shortly after birth with apnea, tachycardia, respiratory grunting, flaring of nostril, cyanosis, chest wall retraction, atelectasis, ground glass appearance with air branchogram.