Let me introduce myself to you!!

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St. Kitts & Nevis
I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!

Wednesday, October 19, 2016

Essential Fructosuria and Hereditary Fructose Intolerance

In this video I have explained about two disorders related with fructose metabolism that is essential fructosuria and hereditary fructose intolerance. Essential fructosuria is due to fructokinase deficiency and hereditary fructose intolerance is due to aldolase B deficiency. Patients with hereditary fructose intolerance will have nausea, vomiting, diarrhea, intolerance to fructose, jaundice, liver damage, kidney damage, convulsion, seizures, coma. Essential fructosuria is asymptomatic condition with only elevated levels of fructose in blood and urine. 

Wednesday, October 12, 2016

One Carbon Metabolism

In this video I have explained about one carbon metabolism reactions and the donors and formation of one carbon derivatives. Tetrahydrofolate (THF) plays a central role in one carbon metabolism. Vitamin B12, B6 and B2 that is cobalamin, pyridoxine and riboflavin, respectively, helps in the formation of one carbon derivatives from THF. One carbon metabolism participates in synthesis of thymidylate monophosphate, C2 and C8 of purine ring, synthesis of glycine from serine and conversion of homocystienine into methionine. 

Why Electrons flow from NADH to O2 in Electron Transport Chain

In this video I have explained the fundamental basis of electron transport chain that is the redox potential of NADH which is a electron donor and O2 which is a final electron acceptor. Electron transport chain which also referred as oxidative phosphorylation or respiratory chain runs with the redox potential difference of 1140 mv between NADH and O2. This drives flow of electrons from NADH to O2 via complex I, CoQ, III, cytochrome C and complex IV. The energy in the flow of electrons helps in pumping of protons across the membrane. 

Pyruvate Dehydrogenase Complex - Regulation

In this video I have explained all the points related to regulation of pyruvate dehydrogenase enzyme complex. Pyruvate dehydrogenase enzyme complex is also written as PDH complex or simple PDC. It has feedback regulation, allosteric modulation, covalent modification mediated by insulin and glucagon. In fasting condition its activity will decrease and in fed condition its activity will increase. NADH, acetyl CoA have a negative effect on PDH, ADP and pyruvate and Ca2+ will have a positive effect on PDH complex.

TCA Cycle - Regulation

In this video I have explained all the points related to regulation of TCA cycle. The main enzyme in regulation of TCA cycle or citric acid or Krebs cycle is isocitrate dehydrogenase. Other enzymes that are regulated are alpha-ketoglutarate dehydrogenase, malate dehydrogenase and citrate synthase. Main molecules regulating are ADP, Ca2+ and NADH+H.