Omega 6 and Omega 3 PUFAs in relation to inflammation

I would like to bring to your attention about Comparison between omega 6 and omega 3 PUFAs with respect to inflammation. 

We are debating here on good vs good, both omega 6 and omega 3 are good for our body in their own way. As we all know inflammation is a good thing but not always, controlled inflammation is a good thing, when inflammation goes uncontrolled that leads to acute and chronic inflammatory diseases. All this mediated by inflammatory mediators which are largely from our two class of PUFAs. Omega 6 and omega-3. 

As you might be knowing we need to get these omega FAs from plant source as linoleic acid (omega 6) and linoleic acid (omega3), in our body linoleic acid is converted arachidonic acid (omeg6) whereas linoleic acid into DHA and EPA (omega3) which are incorporated into membrane. 

In response to injury there will be activation of phospholipase A2 which breaks and release these membrane lipids and further they go on to make inflammatory mediators. 

Arachidonic acid (omega6) largely form pro-inflammatory mediators and increases inflammation including platelet aggregation, it also makes pro-resolving mediators like lipoxins. 

Whereas DHA and EPA will form predominantly anti-inflammatory, pro-resolving and cytoprotectants like E series resolvins, D-series resolvins, protectins, neuroprotectins, meresins which all participate in resolving the inflammation and protecting the cell. 

So by adequately consuming omega3 PUFAs we are trying to keep things in balance and protect from uncontrolled inflammation which could lead to variety of disease conditions include thromboembolism. 

Hence it is all about keeping homeostasis by consuming omega6, omega3, MUFA and saturated fatty acids all in balance because we need all of them but in balance. 

Hope this explanation helps some of you to understand this very important concept.