In this video I have explained in brief about water soluble vitamin biotin. I have touched upon biological functions, enzymes, causes for deficiency and deficiency manifestations.
Biotin is widely available vitamin. it is also significantly synthesized in the intestine by bacterial flora. main function of biotin is it acts as a CO2 carrier for carboxylase enzymes in carboxylation reactions.
Four carboxylases needs biotin as their coenzyme, they are:
- acetyl CoA carboxylase
- pyruvate carboxylase
- propionyl CoA carboxylase
- methylcrotonyl CoA carboxylase
Dietary deficiency of biotin is rare.
Deficiency of biotin is seen in four conditions:
- Prolonged use of antibiotics (which kill bacterial flora)
- Prolonged use of anticonvulsants (interfere with absorption)
- Consumption of raw egg white (avidin binding with biotin).
- Biotidinase deficiency (decreased recycling).
Clinical Manifestation:
Multiple carboxylase deficiency leads to dermatitis, alopecia, diarrhea, opportunistic infections like fungal infection, and central nervous system signs like confusion, depression.
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