Answer to a Question on Uncoupler of Electron Transport Chain

In this video I have explained a question on uncouplers of electron transport chain. Chemical uncouplers are 2,4-Dinitrophenol, dinitrocresol, pentachlorophenaol. Physiological uncouplers are thermogenin, uncoupling proteins UCP1, UCP2, UCP3, UCP4, UCP5. All are present in various tissues like brown adipose tissue, skeletal muscle, brain, neurons, other tissues. Uncouplers increase BMR, body temperature, metabolic rate, increased rate of electron transport, increased O2 consumption, increased respiratory rate.

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Key words:
electron transport chain
uncouplers
2,4-dinitrophenol
thermogenin
T3 and T4
pentachlorophenol
temperature
basal metabolic rate
ATP synthesis
ATP synthase
redox potential
NADH
FADH2
complex I
complex II
cytochrome oxidase
ubiquionone
brown adipose tissue
BAT
UCP
O consumption
NAD
FAD
USMLE
step-1
Kaplan
biochemistry
Review video
Mungli

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