In this video I have explained all the points related to regulation of pyruvate dehydrogenase enzyme complex. Pyruvate dehydrogenase enzyme complex is also written as PDH complex or simple PDC. It has feedback regulation, allosteric modulation, covalent modification mediated by insulin and glucagon. In fasting condition its activity will decrease and in fed condition its activity will increase. NADH, acetyl CoA have a negative effect on PDH, ADP and pyruvate and Ca2+ will have a positive effect on PDH complex.
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- Dr.Prakash Mungli, MD
- St. Kitts & Nevis
- I'm a physician doctor with an MD degree. My passion for teaching has always been appreciated by students with whom I have shared my knowledge. I'm a passionate teacher of medical biochemistry and would like to share my knowledge about this beautiful subject with all those who is interested to learn to understand the cellular metabolic events and to understand the metabolic disease process. I would like to learn new things by keeping myself updated with current research in the field. Let us share the knowledge each other!!
Wednesday, October 12, 2016
Pyruvate Dehydrogenase Complex - Regulation
In this video I have explained all the points related to regulation of pyruvate dehydrogenase enzyme complex. Pyruvate dehydrogenase enzyme complex is also written as PDH complex or simple PDC. It has feedback regulation, allosteric modulation, covalent modification mediated by insulin and glucagon. In fasting condition its activity will decrease and in fed condition its activity will increase. NADH, acetyl CoA have a negative effect on PDH, ADP and pyruvate and Ca2+ will have a positive effect on PDH complex.
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